Progressive neurologic disorder: Initial manifestation of hemophagocytic lymphohistiocytosis

Progressive neurologic disorder: Initial manifestation of hemophagocytic lymphohistiocytosis

Case report. A 14-year-old Caucasian female presented with a 3-month history of headaches, progressive rightsided convergent squint, dysarthria, gait abnormality with progressive difficulty in climbing up the stairs and being able to stand, and hyperesthesia involving her left arm and leg. She had a longstanding history of pervasive refusal disorder for which she was receiving psychiatric suppo...

Hemophagocytic Lymphohistiocytosis and Progressive Disseminated Histoplasmosis.

Progressive Diffuse Osteonecrosis in a Patient with Secondary Hemophagocytic Lymphohistiocytosis

This is a case report with serial imaging showing progression of diffuse osteonecrosis in a patient after a diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH). While bone marrow involvement in HLH has been long noted at histological evaluation and is itself one of the diagnosis criteria, to the best of our knowledge, there has been no previous publication addressing osseous image f...

Hemophagocytic Lymphohistiocytosis

To investigate the clinical features of adult patients with hemophagocytic lymphohistiocytosis (HLH) and to explore possible risk factors for death, we retrospectively reviewed the medical records of 103 adult HLH patients hospitalized from 1997 to 2012. We analyzed the underlying diseases, clinical characteristics, 1aboratory findings, outcomes, and prognostic factors. The most common cause of...

Biology and Treatment of Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistocytosis (HLH) is a hyperinflammatory syndrome that occurs at all ages and is characterized by high levels of cytokines, secreted by activated T-lymphocytes and macrophages. All symptoms and laboratory changes can be explained by organ infiltration by these cells and hypercytokinemia. HLH occurs as an inherited form (genetic, primary HLH) with mutations primarily in the...